Synthesis and antibacterial activity of the sulfonamide based schiff base and its transition metal [II] complexes

ABSTRACT

A Schiff base 3 has been synthesized by equimolar reaction [condensation] of sulfonamide i.e. sulfamethoxypyridazine 1 and substituted aromatic aldehyde i.e. 2-Hydroxy-1-Napthalene aldehyde 2. The synthesized Schiff base 3 and its Metal [II] complexes were characterized by its physical, analytical [CHN analysis] and spectral [UV and IR] analysis. The Staphylococcus aureus and Escherichia coli bacterial strains were used for antibacterial activity of Sulfamethoxypyridazine 1, its Schiff base 3 and its transition metal [II] complexes 4-8. All of them showed varied levels of activity