Evaluating the effect of melatonin on HAS2, and PGR expression, as well as cumulus expansion, and fertility potential in mice

ABSTRACT

Objective: Infertility is a worldwide health problem which affects approximately 15% of sexually active couples. One of the factors influencing the fertility is melatonin. Also, protection of oocytes and embryos from oxidative stress inducing chemicals in the culture medium is important. The aim of the present study was to investigate if melatonin could regulate hyaluronan synthase-2 [HAS2] and Progesterone receptor [PGR] expressions in the cumulus cells of mice oocytes and provide an in vitro fertilization [IVF] approach: