Semaphorin-3A as an immune modulator is suppressed by microRNA-145-5p

ABSTRACT

Objective: Semaphorin-3A [SEMA3A] and its receptors are found on some immune cells and act as suppressors of immune cells over-activation. Considering the role of SEMA3A and its down-regulation in some autoimmune diseases, as well as our bioinformatics predictions, we assumed that miR-145-5p might affect SEMA3A expression. So, we aimed to determine the effect of miR-145-5p on SEMA3A gene expression level