Induction of apoptosis in cancer cells of pre-B All patients after exposure to platelets, platelet-derived microparticles and soluble CD40 ligand

ABSTRACT

Objective: The in vitro treatment of tumor cells with platelet [Plt] causes inhibition of tumor cell growth, although mechanism of this effect is not clear yet. Induction of apoptosis has been proposed as a mechanism of Plt effects on tumor cells. The purpose of this study was to clarify the role of Plts and Plt-derived components in the induction of apoptosis in the blood mononuclear cells of patients with leukemia