Temporary hemodialysis; taurolidine lock to prevent catheter-related blood stream infections
Professional Medical Journal-Quarterly [The]. 2015; 22 (3): 287-292
in English
| IMEMR
| ID: emr-191665
ABSTRACT
Catheter related blood stream infections [CRBSI] in patients undergoing hemodialysis frequently results in significant morbidity and mortality. Attempts at prevention of CRBSI by catheter lock antibiotics, antibiotic combinations or solutions including Taurolidine have emerged over years. Objectives:
To determine the role of taurolidine lock in presentation of Catheter related infection in hemodialysis.Design:
Multicentre un-builded, r and omized controlled, non-inferiority trail. Period Jul 2012 to Dec 2013.Setting:
Department of Nephrology, Fatima Memorial Hospital UHS Lahore.Methods:
It was a multicentre, un-blinded, r and omized controlled, non-inferiority trial.Results:
Out of 95 patients, total of 38 patients were r and omized into two groups. In group A catheters were locked with Taurolidine 2% and Heparin [5000IU/ml] equal to the catheter volume according to the protocol. In group B [control] catheters were locked with Heparin alone. 36 patients completed the study protocol. For primary end point analysis [30 days] the mean duration of catheter days was 27.25 + 5.5 days [median 30 days]. During this period of follow up only one patient from Group B had CRBSI resulting in a point incidence of CRBSI of 2.7%.Conclusions:
Catheter lock with Taurolidine 2% in combination with heparin compared to heparin alone had no additional benefit in prevention of CRBSI. This however needs to be evaluated in a larger study using non cuffed temporary vascular access [TVA]
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Index:
IMEMR (Eastern Mediterranean)
Type of study:
Controlled clinical trial
Language:
English
Journal:
Professional Med. J.-Q
Year:
2015
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