Pharmacokinetic and imaging evaluation of 99mTc-HBIDP as a potential bone imaging agent

ABSTRACT

Developing novel superior bone-seeking radiopharmaceutical for the detection of malignant bone lesions could further improve the diagnostic value of routine bone scanning and shorten the interval between injection and imaging. In order to further evaluate the bone imaging efficiency of 99mTc-HBIDP [1-hydroxy-2-[1-butyl-imidazol-2-yl]-ethane-1, 1-diphosphonic acid], the pharmacokinetic in mice and single photon emission computed tomography [SPECT] bone scanning in rabbit for 99mTc-HBIDP was investigated. Kinetics of blood clearance showed that the distribution half-life [T1/2a] and elimination half-life [T1/2] of 99mTc-HBIDP are 2.73 and 24.87 min, respectively. Excellent bone images can be obtained at 1 h post injection with SPECT bone scanning, which is clearer and quicker than 99mTc-ZL [zoledronate] and 99mTc-MDP [methylenediphosphonate]. All results indicate that 99mTc-HBIDP holds great potential as a novel improved bone imaging agent