Effectiveness and Safety of a 10mg Warfarin Initiation Nomogram in Asian Population
Pakistan Journal of Pharmaceutical Sciences. 2015; 28 (3)
in English
| IMEMR
| ID: emr-191714
ABSTRACT
Anticoagulant responses to warfarin vary among patients, based on genetic factors, diet, concomitant medications, and disease state. We evaluated the effectiveness and safety of a 10mg warfarin initiation nomogram in anAsian population. Retrospective cross-sectional audit studies were conducted from March 2009 to March 2010. The use of a 10mg-loading dose to initiate warfarin treatment resulted in 33[84.6%] patients attaining a therapeutic INR within four days [mean time, 2.6 days]. There was no significant correlation between age, gender, race, and serum albumin for the time to reach a therapeutic INR. A significant correlation was noted for patient's baseline INR and time to reach a therapeutic INR [P<0.05]. No significant differences were observed in time to reach a therapeutic INR in patients treated with specific class of concomitant drugs or patients with specific disease states.The overall incidence of over-anticoagulation was 35.9%; however, no bleeding episodes were encountered. In conclusion, the use of a 10mg warfarin nomogram was effective in rapidly achieving a therapeutic INR. However, the nomogram's safety is debatable owing to the high over-anticoagulation rate warfarin-administered patients. Caution is recommended in the initiation of warfarin reatment using the 10mg nomogram
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2015
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