Homocysteine level according to some cardiac risk factors and extent of coronary disease

ABSTRACT

Hyperhomocysteinemia is accompanied by many cardiovascular risk factors. However it's relation with other cardiac risk factors and with extent of coronary artery disease [CAD] is still a controversial issue. This study was designed to investigate the relationship between total plasma homocysteine [tHcy] levels and other cardiovascular risk factors and the severity of CAD. Fasting plasma tHcy levels were measured in 60 patients with angiographically documented CAD and compared to 56 control subjects matched for age, sex, and smoking habits. Also patients were classified into two groups of low risk [with two or few risk factor] and high risk [with three and more risk factor] according to their major risk factors. Mean of tHcy levels were significantly higher in high risk patients compared to low risk patients [p=0.013]. Also hyperhomocysteinemia rate was higher in the high risk patients compared to low risk patients, OR=5 [CI 95%=1.6-16].There was relationship between coronary risk factors and severe coronary artery disease [three vessels disease] but this relationship was statistically significant only in smokers [P=0.012] and diabetic patients [P=0.035]. Plasma tHcy level was an independent risk factor for high risk patients.