effect of hemodialysis on some acute phase proteins

ABSTRACT

The acute phase proteins, c-reactive protein [CRP], Alpha-antitrypsin [AAT], complement 3 [C3] and fibrinogen were studied in 35 patients with chronic renal failure [CRF] after 1,6 and 12 months of regular hemodialysis [RHD] and also in 15 healthy subjects age and sex matched for comparison. Estimation of serum CEP was done by ELISA technique. Serum AAT, serum C3 and plasma fibrinogen were performed by immunodiffusion technique. Serum CRP levels after 1,6 and 12 Ms of RHD were significantly elevated compared to control. Furthermore, serum levels revealed significant increase when comparing 6 Ms to IM and 12 Ms to 6 Ms of RHD. Serum AAT was significantly elevated after 1 M and RHD compared to control. The serum levels gradually decreased after 6 and 12 Ms of RHD but still insignificantly higher than the controls values. Comparing 6 and 12 Ms with 1 M significant decrease is found. Serum levels of C3 showed significant reduction after 1, 6 and 12 Ms of RHD compared to controls and also when comparing 6 Ms to 1 M of RHD. No significant difference was found between 1 M and 12 Ms of RHD. Plasma fibrinogen was significantly elevated after 1 and 6 Ms of RHD but no significant difference after 12 Ms of RHD as compared to controls. The plasma levels revealed significant reduction when comparing 6 Ms to 1 m and 1 Ms to 6 Ms of RHD