Clinical Evaluation of the Efficacy of Pharmacopeial Unani Formulation in the Management of Taqashshure Jild [Psoriasis]

ABSTRACT

Taqashshure jild [Psoriasis] is a chronic inflammatory skin disorder affecting up to 1-2% of the world's population and clinically characterized by erythematous, sharply demarcated papules and rounded plaques, covered by silvery micaceous scale. The objective of the study was to assess the safety and efficacy of Majoon Ushba and Roghane Hindi in the management of psoriasis. 30 diagnosed patients of psoriasis, qualifying the inclusion criteria, were invited for a clinical trial. The randomized, single blind, placebo controlled study was adopted. The patients were divided randomly into test and control groups after obtaining their informed consent. Test Group comprised 20 patients in which Majoon Ushba 5 grams was given twice daily orally and Roghane Hindi was applied locally twice daily. Control group comprised 10 patients who were given placebo drug orally and topically. The duration of this trial was 8 weeks and follow up was done fortnightly. The severity of Psoriasis and efficacy of the research drug was assessed by PASI Scale. The results of both groups were compared and analyzed statistically by applying a suitable test. The study showed significant reduction in the PASI score in the test group [p<0.01] as compared to placebo. Thus it is concluded that Majoon Ushba and Roghane Hindi can be used safely in the management of psoriasis after considering the safety and effectiveness.