l Comparison of Efficacy of Topical Ofloxacin and Gentamycin in Tubotympanic Type of Chronic Suppurative Otitis Media

ABSTRACT

Objectives: To compare the eficacy of 0.3% topical ofloxacin 4 drops thrice daily with topical gentamycin 0.3%, 4 drops thrice daily in patients with active tubotympanic type of CSOM. Study Design: Randomized controlled trial study. Place and Duration of Study This study was carried out in the Department of ENT and Head and Neck Surgery, HMC, Peshawar from Jan 2012 to July 2012. Materials and Methods: This Randomized controlled trial was conducted, consisting of 134 patients with ear discharge for more than three months which were randomly allocated to two groups each consisting of 67 patients. Patients in group A received gentamycin 0.3% in a dosage of four drops thrice daily, while patients in group B received 0.3 % ofloxacin four drops thrice daily for ten days. Patients were followed for two weeks after therapy for ear symptoms assessment, otoscopy and examination under microscopy. Results: A total of 134 patients of chronic suppurative otitis media were included in the study. Results showed that the rate of resolution of ear discharge [otorrhea] is significantly higher in patients treated with topical Ofloxacin than gentamycin [98.5% vs 89.6%]. [Pc0.05] Conclusion: Topical Ofloxocin is a better choice in management of CSOM than topical Gentamycin in terms of resolution of ear discharge.