Comparison of serum vitamin D and plasma PTH levels between prc and post-menopausal females at tertiary care hospital in Rawalpinidi

ABSTRACT

Objective: To determine the relationship between increasing age of females and falling levels al vitamin D [25 [OH] D] and PTH. Materials and Methods: It was a comparative cross sectional study conaucted in conformance with good clinical praclices. It was conduted at Fauji Foundation Hospital Rawalpindi from May 2009 to May 2011. Females 15-35 years of age [group 1] and in all female patients above 50 years of age [group 2] were included. Both groups comprised participants from the lowe socioeconomic strata. Results: In group 1, mean age was 22.38 years. Serum 25 [OH] D levels ranged from 4 nmol/L 250 nmol/L. Plasma PTH levels ranged from 4 pg/ml to 35.4 pg/ml. In group 2, age range af patienls 50 - 86 years and mean age in this group of paticrds was 60.37 years. Serum 25 [OH] D Icvrsls range from 4 nmol/L to 123 nmol/L. Plasma PTH levels ranged from 9.2 pg/ml to 218 pg/ml. By the USA of a culoff of 20 nmol/l, 23% women less than 35 years of age and 42% women above 50 years of age were classified as having a vitamin D deficiency. By the us of a cutoff of 50 nmol/l, 65% women less than 35 years of age and 51% of women above 55 years of age were classified as having a vitamin D insufficiency. Correlation studies between age and 25 [DH] D of both groups showed negative correlation; hence signify that increasing age of pelients result in hllir.ly 25 [OH] D levels. Conclusions: Scrum 25 [OH] D levels were significantly lower in post-menopairsal woman as compared to premenopausal. Plasma PTH levels had a negative correlation with serum 25 [OH] D with increasing age