Declined plasma sfrp5 concentration in patients with type 2 diabetes and latent autoimmune diabetes in adults

ABSTRACT

Objective: Secreted frizzled-related protein 5 [sfrp5], like adiponectin, has been identified as a novel insulin-sensitising and anti-inflammatory adipokine. Our objective was to determine whether differences of circulating plasma sfrp5 concentration exist among type 2 diabetes [T2D], latent autoimmune diabetes in adults [LADA] and healthy population. Methods: Enzyme-linked immuno sorbent assay was employed to detect the circulating sfrp5 level in plasma, and other lab tests such as fasting glucose and creatinine were also examined. Correlation analysis between sfrp5 and characteristics of subjects was conducted IBM SPSS Statistics and GraphPad Prism. Results: Circulating sfrp5 level was significantly decreased in T2D and LADA patients plasma compared with that in healthy control [14.14+/-11.91ng/mL, 14.82+/-11.27ng/mL, 22.98+/-12.36ng/mL, respectively], although no differences was observed between LADA and T2D groups. Furthermore, we found sfrp5 was correlated with homeostasis model assessment of insulin resistance [HOMA-IR], diabetes duration and BMI. Finally we found sfrp5 was still negatively correlated with HOMA-IR after being adjusted for disease duration and BMI[r= -0.315, P< 0.05]. Conclusions: Our results support a role for SFRP5 as a protective factor in the pathogenesis of autoimmune diabetes and facilitate a novel aspect for diabetes research