Correlation between genetic polymorphism of matrix metalloproteinase-9 in patients with coronary artery disease and cardiac remodeling

ABSTRACT

Objective: To explore the correlation between genetic polymorphism of matrix metalloproteinase-9 [MMP- 9] in patients with coronary artery disease [CAD] and cardiac remodeling. Methods: A total of 272 subjects who received coronary angiography in our hospital from July 2008 to September 2013 were selected, including 172 CAD patients [CAD group] and another 100 ones [control group]. Both groups were subjected to MMP-9 and ultrasonic detections to determine vascular remodeling and atherosclerotic plaques. C1562G polymorphism of MMP-9 gene was detected, and correlation with vascular remodeling and atherosclerotic plaque was analyzed. Results: Serum MMP-9 level of CAD group [330.87+/-50.39 ng/ml] was significantly higher than that of control group [134.87+/-34.02 ng/ml] [P<0.05]. Compared with control group, CAD group had significantly higher intima-media thickness, and significantly lower systolic peak velocity, mean systolic velocity and end-diastolic velocity [P<0.05]. Total area of stenotic blood vessels was 67.34+/-22.98 mm2, while that of control blood vessels was 64.00+/-20.83 mm2. G/G, G/C and C/C genotype frequencies of MMP-9 differed significantly in the two groups [P<0.05]. G and C allele frequencies of CAD group [70.9% and 29.1%] were significantly different from those of control group [50.0% and 50.0%] [P<0.05]. G/G, G/C and C/C genotypes were manifested as lipid-rich, fibrous and calcified or ulcerated plaques respectively. Total area of stenotic blood vessels of G/G genotype significantly exceeded those of G/C and C/C genotypes [P<0.05], whereas the latter two had no significant differences. Conclusion: CAD promoted 1562C-G transformation of MMP-9 gene into genetic polymorphism, thus facilitating arterial remodeling and increasing unstable atherosclerotic plaques