The imbalaace in expression of angigenic and anti- angiogenic factors as candidate predictive biomarker in preeclampsia

ABSTRACT

Preeclampsia is an importait pregnancy disorder with serious maternal and fetal complications uliich its etiology has not been conlpletely understood yet. Early diagxosis and management of disease could reduce its potential side effects. The vascular endothelial growth Factor [VEGF] family including VEGF-A is the most potent endothelial growth factor which induces angiogenesis and endotheha1 cell proliferation and has basic role in vasculogenesis. VEGF and its tyrosine kinase receptors [Fltl and 1U]R] are major factors for fetal and placental aigiogenic development. Finding mechanisms involved in expression of angiogenic factors may lead to new prognostic and therapeutic points in management of preeclampsia. Recent researches, has shown capability of some antiangiogenic factors as potential candidate to be used as early predictors for preeclampsia. Soluble fins-like tyrosin lcinase-1 [sFltl] is a truncated splice variant of the membrane-bound VEGF receptor Fltl, that is produced by the placenta and it can bind to angiogenic gsowth factors and neutraliz, their effects. It is also observed that the ratio of sFItl to placental growth factor is valuable as prognostic marker. In this review, VEGF family member's role in angiogenesis is evaluated as biomarkers to be used for prediction of preeclampsia.