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DNA Wow cytmetric analysis in vsriab$e types of hydropic placentas
IJRM-Iranian Journal of Reproductive Medicine. 2015; 13 (5): 269-274
in English | IMEMR | ID: emr-192117
ABSTRACT

Background:

Differential diagnosis between complete hydatidiform mole, partial hydatidiform mole and hydropic abortion, known as hydropic placentas is still a challenge for pathologists but it is very important for patient management.

Objective:

We analyzed the nuclear DNA content of various types of hydropic placentas by flowcytometry. Materials and

Methods:

DNA ploidy analysis was performed in 20 non-molar [hydropic and non-hydropic spontaneous aboltions] and 20 molar [complete and partial moles], formalin-fixed, paraffin-embedded tissue samples by flow cytometry. The criteria for selection were based on the histopathologic diagnosis.

Results:

Of 10 cases histologically diagnosed as complete hydatiform mole, 9 cases yielded diploid histograms, and 1 case was tetraploid. Of 10 partial hydatidiform moles, 8 were triploid and 2 were diploid. All of 20 cases diagnosed as spontaneous abortions [hydropic and non-hydropic] yielded diploid histograms.

Conclusion:

These findings signify the importance of the combined use of conventional histology and ploidy analysis in the differential diagnosis of complete hydatidiform mole, partial hydatidiform mole and hydropic abortion
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Index: IMEMR (Eastern Mediterranean) Language: English Journal: Iran. J. Reprod. Med. Year: 2015

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Index: IMEMR (Eastern Mediterranean) Language: English Journal: Iran. J. Reprod. Med. Year: 2015