Role of mitogen-activated protein kinases in the formation of hypertrophic scar with model of lipopolysaccharide stimulated skin fibroblast cells

ABSTRACT

Objective: Hypertrophic scar is common in burn patients, but treating result could not meet the expectation of the patients and doctors. We have found that certain concentration level of lipopolysaccharide [LPS] stimulated normal fibroblast cells have statistically similar with fibroblast cells from hypertrophic scar on the phenotype level, and with this work we are trying to figure out which Mitogen-Activated Protein Kinase [MAPK] is affected and how it is affected