IBJ-Iranian Biomedical Journal. 2018; 22 (2): 99-106
in English
| IMEMR
| ID: emr-192456
ABSTRACT
Background:
Acute myeloblastic leukemia [AML] is a clonal disorder due to bone marrow failure and uncontrolled proliferation of myeloid lineage. Acute promyelocytic leukemia [APL] is a subtype of AML. Heterocyclic compounds, such as indole, are considered as attractive candidates for cancer therapy, due to their abundance in nature and known biological activity. Sal-like protein [SALL4] is a zinc finger transcription factor involving in the multi-potency of stem cells, in the NB4 cell line. This study was aimed to evaluate the effects of basal indole and its new derivative, 2-[1-[[2, 4-Aril]imino]-2,2,2-trifluoroethyl] phenyl-1H Indole-3- carbaldehyde [TFPHC], on the expression of SALL4
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Transcription Factors
/
Gene Expression
/
Cells, Cultured
/
Cell Line, Tumor
/
Promyelocytic Leukemia Zinc Finger Protein
/
Indoles
Language:
English
Journal:
Iran. Biomed. J.
Year:
2018
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