Lipid peroxidation and its role in the expression of NLRP1a and NLRP3 genes in testicular tissue of male rats: a model of spinal cord injury

Mahshid, Bazrafkan; Banafsheh, Nikmehr; Abdolhossein, Shahverdi; Seyed, Hosseini; Fatemeh, Hassani; Mahnaz, Poorhassan; Tahmineh, Mokhtari; Farid, Abolhassani; Hamid, Choobineh; Cordian, Beyer; Gholamreza, Hassanzadeh

Mahshid, Bazrafkan; Banafsheh, Nikmehr; Abdolhossein, Shahverdi; Seyed, Hosseini; Fatemeh, Hassani; Mahnaz, Poorhassan; Tahmineh, Mokhtari; Farid, Abolhassani; Hamid, Choobineh; Cordian, Beyer; Gholamreza, Hassanzadeh.

IBJ-Iranian Biomedical Journal. 2018; 22 (3): 151-159

in English | IMEMR | ID: emr-192464

ABSTRACT

ABSTRACT

Background:

The majority of male patients with spinal cord injury [SCI] suffer from infertility. Nucleotide-binding oligomerization domain-like receptors NOD-like receptors [NLRs] are a kind of receptors that corporate in the inflammasome complex. Recent studies have introduced the inflammasome as the responsible agent for secreting cytokines in semen. Reactive oxygen species [ROS] is one of the elements that trigger inflammasome activation. Genital infections in SCI can lead to ROS generation. We investigated the relation between lipid peroxidation and inflammasome complex activity in testicular tissue of SCI rats

Subject(s)

Animals, Laboratory; Infertility; Lipid Peroxidation/genetics; NLR Family, Pyrin Domain-Containing 3 Protein; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Gene Expression; Testis; Rats, Wistar

Search on Google

XML

Index: IMEMR (Eastern Mediterranean) Main subject: Testis / Lipid Peroxidation / Gene Expression / Reactive Oxygen Species / Rats, Wistar / Real-Time Polymerase Chain Reaction / NLR Family, Pyrin Domain-Containing 3 Protein / Infertility Limits: Animals Language: English Journal: Iran. Biomed. J. Year: 2018

Similar

MEDLINE

LILACS

LIS

Search on Google

XML