Nanocurcumin-mediated down-regulation of telomerase via stimulating TGF beta 1 signaling pathway in hepatocellular carcinoma cells

Molood, Shariati; Samira, Hajigholami; Ziba, Malekshahi; Maliheh, Entezari; Narges, Bodaghabadi; Majid, Sadeghizadeh

Molood, Shariati; Samira, Hajigholami; Ziba, Malekshahi; Maliheh, Entezari; Narges, Bodaghabadi; Majid, Sadeghizadeh.

IBJ-Iranian Biomedical Journal. 2018; 22 (3): 171-179

in English | IMEMR | ID: emr-192466

ABSTRACT

ABSTRACT

Background:

Curcumin, extracted from turmeric, represents enormous potential to serve as an anticancer agent. Telomerase is viewed as a prominent molecular target of curcumin, and transforming growth factor- beta 1 [TGF beta 1] has proven to be a major inhibitory signaling pathway for telomerase activity. In the current study, we aimed to explore suppressive effects of nanocurcumin on telomerase expression through TGF beta 1 pathway in a hepatocellular carcinoma cell line [Huh7]

Subject(s)

Animals, Laboratory; Liver Neoplasms/therapy; Liver Neoplasms/genetics; Curcumin/therapeutic use; Telomerase; Gene Expression; Transforming Growth Factor beta1

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Index: IMEMR (Eastern Mediterranean) Main subject: Gene Expression / Telomerase / Curcumin / Transforming Growth Factor beta1 / Liver Neoplasms Limits: Animals Language: English Journal: Iran. Biomed. J. Year: 2018

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