Development of a DNA aptamer for screening neisseria meningitidis serogroup B by cell SELEX
IBJ-Iranian Biomedical Journal. 2018; 22 (3): 193-201
in English
| IMEMR
| ID: emr-192468
ABSTRACT
Background:
Artificial oligonucleotides like DNA or RNA aptamers can be used as biodiagnostic alternatives for antibodies to detect pathogens. Comparing to antibodies, artificial oligonucleotides are produced easily at lower costs and are more stable. Neisseria meningitidis, the causative agent of meningitis, is responsible for about 1% of infections in an epidemic period. Specific DNA aptamers that bind to N. meningitidis serogroup B were identified by whole-cell Systemic Evolution of Ligands by EXponential Enrichment [SELEX]
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Neisseria meningitidis, Serogroup B
/
Aptamers, Nucleotide
/
SELEX Aptamer Technique
/
Flow Cytometry
Type of study:
Screening study
Language:
English
Journal:
Iran. Biomed. J.
Year:
2018
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