Clinical utility of circulating MicroRNA-21 in breast cancer
Egyptian Journal of Hospital Medicine [The]. 2018; 71 (4): 2950-2955
in English
| IMEMR
| ID: emr-192551
ABSTRACT
Background:
Breast cancer remains the most frequent type of cancer in females worldwide, with nearly 1.7 million new cases diagnosed in 2012. In Egypt, breast cancer is the most common malignancy among females accounting for 18.3% of total cancer cases in Egypt. Unfortunately, the traditional imaging techniques as well as the currently accepted markers such as serum CEA and CA 15.3 cannot adequately identify early stage patients. MiRNAs are a class of endogenous non-coding RNAs tilde 22 nucleotides in length, which regulate gene expression primarily at the post-transcriptional level and thus are involved in many cellular processes, such as cell proliferation, differentiation, and apoptosis. One of which is miRNA-21 and its alterations have been shown to play critical roles in breast cancer
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Breast Neoplasms
/
Case-Control Studies
/
Pilot Projects
/
Retrospective Studies
/
Mucin-1
Type of study:
Screening study
Limits:
Female
/
Humans
Language:
English
Journal:
Egypt. J. Hosp. Med.
Year:
2018
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