Blockage of HCN channels with ZD7288 attenuates mechanical hypersensitivity in rats model of diabetic neuropathy

ABSTRACT

Background: Diabetes is a chronic condition that affects millions of people worldwide. The disease can have severe impact on many systems of the human body particularly the nervous system. Indeed, chronic peripheral nerve pain, also known as peripheral neuropathic pain [NP], is the most common complication caused by diabetes. There have existed preclinical researches that were performed using different types of Rodents as models of Chronic Pain. Such studies have proven that hypersensitivity to pain is caused, at least partially, by increased excitability of primary afferent dorsal root ganglion [DRG] neurons that send the sensory information from the periphery to the brain. However, the mechanism of this hyperexcitability is yet to be known