development of a chemiluminescenceimmuno-assay for the measurement of estradiol in saliva

ABSTRACT

An assay for the measurement of the minute concentrations of oestradiol in saliva using the novel and non-isotopic technique of chemiluminescence immunoassay is described. The assay has a high degree of sensitivity, specificity, precision and hence accuracy. The serial determination of oestradiol in the saliva of 13 human volunteers with regular cycles shows a well defined pattern similar to that of its concentration in plasma