Study of the hepatoprotective activity of methanolic extract of feijoa sellowiana fruits against MDMA using the isolated rat liver perfusion system

ABSTRACT

Liver injury induced by viruses, chemicals and drugs can be protected by different medicinal plants. Feijoa sellowiana [Myrtaceae] is an evergreen bush native to southern areas of South America, as well as Iran where the fruits are very popular. Feijoa has shown a potent antimicrobial effect. Morever, the antioxidant activity of total Feijoa extract has also been reported. MDMA or ecstasy is a ring-substituted amphetamine derivative which has been abused as a widespread recreational drug by the young generation. Liver is a target organ for MDMA toxicity. In fact, this sense MDMA is metabolized by cytochromes P[450]2D, 2B and 3Aand reactive metabolites are readily oxidized to the corresponding o-qiuinones and reactive oxygen species [ROS]