study of urinary estrogen glucuronides in ultrasound monitored patients treated with human menopausal gonadotropins

ABSTRACT

Urinary concentrations of estrone-3-glucuronide [E1-3-G], estradiol- 17-beta glucuronide [E2-7b-G] and estriol-16-alpha glucuronide [E3- 16a-G] were determined in 36 cycles in women treated with human menopausal gonadotrophins and monitored with ultrasound scanning of their ovarian follicles. The results showed a good correlation between the concentration of total estrogens and each of the metabolites concentration in 24 hour collections of urine. The rate of increase in the concentration of the three urinary metabolites was exponential and the best temporal regression with log 10 concentration of the three metabolites was found with E1-3-G. It was concluded that ultrasound scanning of follicles combined with the determination of E1-3-G in 24 hour collections of urine is an ideal combination of a biophysical parameter and a simple biochemical parameter for monitoring gonadotrophin therapy. A chart was constructed combining both parameters to help determine the best timing for HCG administration