relationship between hyperlactacidaemia and uric acid clearance in acute fetal distress

ABSTRACT

Fifteen women in labor with acute fetal distress were studied by determining the concentration of lactic acid and uric acid in both maternal serum and fetal cord blood as well as by studying the maternal uric acid clearance. The findings were compared to those in fifteen women in spontaneous uncomplicated deliveries. The results showed that there was a significant increase in lactic acid concentrations in maternal and cord blood in cases of fetal distress than in the normal control cases and that this increase was significantly higher in cord blood than in maternal blood. There was no significant difference in serum uric acid concentrations between cases of acute fetal distress and the normal controls and there was no correlation between maternal blood lactic acid and uric acid concentrations. There was also no significant difference in maternal uric acid clearance between cases of acute fetal distress and normal controls or between maternal lactic acid concentrations and uric acid clearance. It was concluded that in cases of acute fetal distress, the resulting hyperlactacidemia does not alter renal h and ling of uric acid and that lactic acid has no major physiological role in the regulation of blood uric acid or its renal excretion in these cases