Protective effects of water extract of Morus Nigra L. on 6-Hydroxydopamine induced Parkinson's disease in male rats

ABSTRACT

Background: Parkinson's disease [PD] is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Although the etiology of PD is unknown, but major biochemical processes such as oxidative stress is largely described. Angiotensin II activates NADPH depending oxidases and produce superoxides formation. Morus nigra L. extract is an Angiotensin Converting Enzyme [ACE] inhibitor and tested for anti-Parkinsonism effects by biochemical and behavioral evaluations