Comparison between the effect of oral bromocriptine and bromocriptine injections on serum prolactin level in pathological hyperprolactinemia

ABSTRACT

The study included 20 females with hyperprolactinemia of different causes. They were subjected to careful history taking and physical examination. The basal serum prolactin and thyroid stimulating hormone [TSH] were assayed. Fundus examinations, plain X- ray skull and cat scan were done in some cases. Ten cases were given 7.5 mg oral bromocriptine daily for three months. The other ten cases were given long acting bromocriptine in repeated injections [LAR] in a dose of 50 mg monthly for three months. There were no significant differences in the efficacy of parlodel tablets and injections in suppressing serum prolactin. Also, no significant difference in the clinical efficacy was found except a more significant effect for the injections in galactorrhea. The number of cases with side effects was equal but its duration was shorter with the injections. Parlodel LAR injections can be repeatedly used without any side effects especially in patients who cannot tolerate the gastrointestinal side effects of the oral tablets and in galactorrhea cases