Overexpression of endometrial estrogen receptor-alpha in the window of implantation in women with unexplained infertility

ABSTRACT

Background: Failure in the endometrial receptivity may account for a significant number of infertility cases including unexplained infertility in women. Reduction in the endometrial estrogen receptor-alpha [ER-alpha] expression during implantation may be a critical event that coincides with the expression of specific genes and the formation of a receptive endometrium. The aim of the present study was to assess the expression of ER-alpha in the mid-secretory phase in the endometrium of women with unexplained infertility