Optimization of effective minerals on riboflavin production by Bacillus subtilis subsp. subtilis ATCC 6051 using statistical designs

ABSTRACT

Background: Riboflavin [vitamin B2] is an essential component of the basic metabo-lism, and an important nutritional and growth factor in humans, animals, plants and micro-organisms. It has been widely used in the fields of pharmaceuticals, feed and food additives. The industrial production of riboflavin mostly relies on the microbial fermentation. Designing an appropriate fermentation medium is of crucial importance to improve the riboflavin production