Synthesis, characterization and biological screening of 5-substituted-1,3,4-oxadiazole-2yl-N-[2-methoxy-5-chlorophenyl]-2-sulfanyl acetamide
Pakistan Journal of Pharmaceutical Sciences. 2013; 26 (2): 345-352
in English
| IMEMR
| ID: emr-193734
ABSTRACT
In the current study, a series of 5-substituted-1,3,4-oxadiazole-2yl-N-[2-methoxy-5-chlorophenyl]-2-sulfanyl acetamide was synthesized by converting variously substituted/unsubstituted aromatic organic acids successively into the corresponding esters, hydrazides and then 5-substituted-1,3,4-oxadiazole-2-thiols. Finally the target compounds were obtained by stirring 5-substituted-1,3,4-oxadiazole-2-thiols with N-[2-methoxy-5-chlorophenyl]-2-bromoacetamide in the presence of N,N-dimethyl formamide [DMF] and sodium hydride [NaH]. The structures of the synthesized compounds were confirmed based on [1]H-NMR, IR and mass spectral data. The synthesized compounds were screened against acetylcholinesterase [AChE], butyrylcholinesterase [BChE] and lipoxygenase enzymes [LOX] and were found to be relatively more active against acetyl cholinesterase
Search on Google
Index:
IMEMR (Eastern Mediterranean)
Type of study:
Screening study
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2013
Similar
MEDLINE
...
LILACS
LIS