Variability of the cyclin-dependent kinase 2 flexibility without significant change in the initial conformation of the protein or its environment; a computational study

ABSTRACT

Background: Protein flexibility, which has been referred as a dynamic behavior has various roles in proteins' functions. Furthermore, for some developed tools in bioinformatics, such as protein-protein docking software, considering the protein flexibility, causes a higher degree of accuracy. Through undertaking the present work, we have accomplished the quantification plus analysis of the variations in the human Cyclin Dependent Kinase 2 [hCDK2] protein flexibility without affecting a significant change in its initial environment or the protein per se