Antisperm, anticardiolipin and antithyroglobulin antibodies in sera and cervical secretions among women with unexplained infertility attending Gynecological and Obstetric Department of Benha University Hospital

ABSTRACT

Background/Aim Unexplained infertility constitutes around 15% of patients presenting with infertility. It is claimed today that unexplained infertility is often associated to immunologic factors. This condition may be a result of autoimmunity [in man and woman] or of isoimmunity [in woman]. Antisperm antibodies [ASA] are detected in 7 to 15 % of men and in 13 to 80 % in women with unexplained infertility. There is some evidence suggests that anti-thyroid antibodies [ATA] could exert a negative influence on the female reproductive potential. The elevated levels of anticardiolipin [aCL] in women with unexplained infertility yielded a hypothesis of pathogenetic involvement of aPL in unexplained infertility. The aim of this study was to determine the immunologic aspect in idiopathic infertility by detecting Non-organ specific [aCL], [ASA] and [ATA] antibodies in patients with unexplained infertility