Rapid versus conventional diagnosis of clarithromycin resistant helicobacter pylori among high risk patients with gastritis in specialized medical hospital "SMH", Mansoura, Egypt

ABSTRACT

Background: Helicobacter pylori [H. pylori] plays a crucial role in the pathogenesis of gastroduodenal diseases. Eradication of H. pylori has been shown to reduce the risk of recurrent peptic ulcer diseases and even the development of gastric cancer. Clarithromycin based triple therapy for 7 to 14 days is currently the first line therapy. Resistance to Clarithromycin is the major reason for eradication failure. Therefore, the detection of antibiotic resistance is crucial in the management of PL pylori infection. The aim of this study was to determine the eradication rate ofH. pylori in SMH outpatients with chronic gastritis exposed to different risk factors and to assess the effect of Clarithromycin resistance on H. pylori eradication using FISH technique and comparing the results with conventional PCR and E-tests