Expression of CycIooxygenase-2[COX-2] and Interleukin-8 [IL-8] in H. pylori gastritis; a study on diagnostic methods and pathological effects of h. pylori infection in dyspeptic patients

ABSTRACT

Background H. pylori infection causes diverse clinical outcomes, including dyspepsia, peptic ulceration, gastric carcinoma and mucosa associated lymphoid tissue [MALT] lymphoma. Up-remulation of COX-2 has been observed in H. pylori gastritis in response to inflammatory cytokines. IL-8 is a major activator for neutrophils which contribute to mucosal damage in H. pylori infected patients. A wide-spread use of non-invasive simple diagnostic method is indicated for diagnosis and follow-up of H. pylori infection