Evaluation of plasma creatine phosphokinase [CPK] level following a single injection of methotrexate as a predicates of treatment success in ectopic pregnancy

ABSTRACT

Objective: To evaluate the plasma creatine phosphokinase [CPK] level after a single Injection of methotrexate [MIX] as a predictor of treatment success in ectopic pregnancy [EP]. Materials and methods: In this prospective study, seventy nine women older than 18 years treated with methotrexate for ectopic pregnancy were evaluated for CPK and p-subunit of human chorionic gonadotropin [3hCG] levels, while they received intramuscular MIX at a dose of 50 mg/m2. The day of injection was considered as day 1 [Dl]. CPK level on Dl was compared between the group l [as treatment success group], treated by a single MIX injection, and the group 2, treated by two or three MIX injections or by surgery