Effect of ascorbic acid on force frequency relationship of skeletal muscle fibers in long term cold exposed sprague dawley rats

ABSTRACT

BACKGROUND: On exposure to prolonged cold temperature, the body responds for effective heat production both by shivering and nonshivering thermogenesis. Cold exposure increases the production of reactive oxygen species which influence the sarcoplasmic reticulum Ca release from the skeletal muscles and affect their contractile properties. The role of ascorbic acid supplementation on force-frequency relationship of cold exposed skeletal muscles was evaluated in this study