[CD4[+] immune response to cytomegalovirus [CMV] in healthy carriers and hematological malignancies]

ABSTRACT

Background and aim: Cytomegalovirus [CMV] infects the majority of human population in their life time and triggers strong immune responses from all arms of the immune system. However the cellular immune response is the major mechanism by which CMV replication is controlled. CMV-specific CD4[+] T cells have a substantial role in maintenance of CMV-specific CD8+ T cell response. The aim of the study was an overview of CD4[+]T cell response to CMV in healthy donors and patients with hematological malignancies