Effect of Chemotherapy on Zinc, Copper, Vitamin D levels and inflammatory marker in adult acute lymphoblastic leukemia

ABSTRACT

Background: In acute lymphoblastic leukemia [ALL] the bone marrow loses its ability in the differentiation and maturation of blood cells at different stages. Zinc and copper are important co-factors for several enzymes and play an important role in maintenance of DNA integrity. Changes in serum levels of zinc and copper have been found in lymphoproliferative disorders. In the present study, the aim was to compare serum levels of zinc, copper, vitamin D, and inflammatory markers after eight courses of chemotherapy