Levofloxacin: a broad spectrum potent antibiotic

ABSTRACT

Levofloxacin is a third generation· fluoroquinolone antibacterial agent with a broad spectrum activity against Gram-positive, Gram-negative bacteria and atypical pathogens. It shows its bactericidal activity by inhibiting topoisomerase IV and DNA gyrase. Levofloxacin has shown Strong antibacterial action against Staphylococcus species, Streptococcus pyogenes, Streptococcus pneumoniae. Staphylococcus haemolyticus, Enterobacter species, Escherichia coli, Salmonella species Klebsiella species Serratia species, Enterococcus species; Proteus. Species, Pseudomonas aeruginosa, Haemophilus injluenzae and Neisseria gonorrhoea. Moreover, levofloxacin has shown antifungal activity against Chlamydia trachomatis it is also active against penicillin resistant Streptococcus pneumoniae. It also possesses lethal effect on resistant mycobacteria like Mycobacterium tuberculosis and Mycobacterium leprae causing tuberculosis and even Mycoplasma species of HIV infection. Levofloxacin is indicated in the treatment of urinary tract infection, respiratory tract infection, biliary tract 'infection and other infection with clinical efficacy of 80-92%