Community-acquired urinary tract infections in Tanta, Egypt: aetiology and antibiotic resistance pattern

ABSTRACT

Treatment of community acquired urinary tract infections [CA-UTIs] in Egypt is usually based on empirical drugs. So, this study was conducted to determine the most common causative organisms and their antibiotic susceptibility aiming at evaluation of empirical drugs used and its modification if necessary. Urine samples from 192 patients with CA-UTI were cultured on suitable media and its sensitivity to different antibiotics were tested where 136 out of them showed positive growth. Gram positive cocci isolated from 13.97% of cases whereas gram negative bacilli from 84.56% and candida was 1.47% . The commonest organisms isolated were Escherichia coli [61.76%] and Klebsiella species [12.5%] followed by Enterococcus [7.35%] and Staph. Aureus [6.61%]. The widest coverage against gram negative bacilli isolates was done by imipenem, [100%], followed by amikacin [90.4%], and Nitrofurantoin [66%]. On the other hand, the least effective antibiotic was Ampicillin/sulbactam [4.3%]. While the best sensitivity against gram positive cocci isolate was done by vancomycin [100%], followed by Nitrofurantoin [95%], Amoxicillin/ clavulanic acid and Ampicillin/sulbactam [60%]. There were also high percentages of multidrug resistant gram negative bacilli in the current work [58.26%] with 32.65% of them showed positive extended spectrum beta lactamase