Effects of chronic cigarette smoking on behavior, EEG power spectrum, EEG activation ratio and visual evoked potential of freely moving rats
Egyptian Journal of Biophysics and Biomedical Engineering. 2006; 7 (1): 55-70
in English
| IMEMR
| ID: emr-196150
ABSTRACT
The present study was carried out to determine the effects of chronic tobacco smoking on behaviour, EEG power spectrum, EEG activation ratio and visual evoked potential [VEP] of freely moving rats. Simultaneous EEG records from the 4 electrodes were carried out one week later [as recovery and raining period] by means of differential recording of 12 channel EEG machine [Braintronix]. Sixty seconds EEG free of artifact were recorded after a tobacco smoking period of 15 min [0.01 mg/200 g] via inhalation route. FFT analysis was carried out for each actual trace to obtain power spectrum density for the recorded 60s period. Chronic Tobacco smoking over a period of 30 days of continuously daily single dose [0.01 mg/200 of rat per day] resulted in arousal increments as some behavioural activation [slight locomotor activation, periods of sniffing]. Also, there was less stimulant effects in the right than left hemisphere. Chronic Tobacco smoking over a period of 30 days of continuously daily single dose [0.01 mg/200 g or rat per day] resulted in Arousal increments as some behavioural activation [slight locomotor activation, periods of sniffing]. Also, there was less stimulant effects in the right than left hemisphere. Chronic Tobacco smoking resulted in decreases in percentage of relative power of delta-1, delta-2, theta-1, theta-2 and alpha-1 and increased percentage of relative power of alpha-2, beta-1 and beta-2 of brain waves. Hemispheric asymmetries were also assessed. When VEP analysis was done there were no differences between tobacco exposed and the unexposed condition. Also, there was a frequency shift of about 0.75 Hz in the alpha-1 frequency toward the higher frequency
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Egypt. J. Biophys. Biomed. Eng.
Year:
2006
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