Effect of growth hormone treatment on height velocity of children with pycnodysotosis

ABSTRACT

Objective: Pycnodysostosis is a rare autosomal recessive osteochondrodysplasia resulting from osteoclast dysfunction. Growth hormone [GH] secretion impairment and low insulin growth factor 1 [IGF-I] concentrations have been reported in these patients. The present study aims to describe GH effect on linear growth of eight children with pycnodysostosis