Co-administration of metformin and N-acetyl cysteine fails to improve clinical manifestations in PCOS individual undergoing ICSI

ABSTRACT

Background: Studies have demonstrated the efficacy of metformin [MTF] in reducing insulin resistance and N-acetyl cysteine [NAC] in inhibiting oxidative stress which are involved in the pathogenesis of polycystic ovarian syndrome [PCOS]. We aimed to compare the effects of MTF and NAC combination on serum metabolite and hormonal levels during the course of ovulation induction in PCOS individual candidates of intracytoplasmic sperm injection [ICSI]