[ effect of beforehand and simultaneous oral contraceptive administration on urine total and free morphine concentration in tolerance and dependency models of rat]

ABSTRACT

Background: Addiction to opioid drugs is considered as a problem throughout the world. Addiction can be studied concerning social, medical and psychological aspects. The social aspect of addiction is quite important. For example, the negative result of addiction test is a requirement for marriage and job by law. On the other hand, frauds in addiction tests have been reported [such as displacement of urine from bladder, alkalization or acidification of urine and taking of diuretics or oral contraceptives]