Condensed pyrimidines XIII
Egyptian Journal of Pharmaceutical Sciences. 1991; 32 (3-4): 441-455
in English
| IMEMR
| ID: emr-19743
ABSTRACT
Acylation of the enaminonitriles was carried out using halogenated acid chlorides yielding substituted alkyl halides. The chlorine atom in the chloroalkyl moiety was replaced by different amines or condensed with thiourea and the formed salts were hydrolized to give the thioalkyl compounds. Moreover, enaminonitriles were reacted with oxalyl chloride to afford the 3-chlorocarbonyl derivatives from which esters and amide were prepared. The 3-carboxylic acid derivatives were also prepared and subjected to decarboxylation. Compounds containing the pyrimidine ring represent an important group of heterocyclic compounds that draw attention for their biological activities
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Drug Compounding
/
Nitriles
Language:
English
Journal:
Egypt. J. Pharm. Sci.
Year:
1991
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