Detection of urinary CD4TCell in patients with lupus nephritis during activity and treatment period

ABSTRACT

Background: Renal involvement is common in Systemic Lupus Erythromatosis [SLE] and is a significant cause of morbidity and mortality. It is estimated that as many as 90% of patients with SLE will have pathologic evidence of renal involvement on biopsy, but clinically significant nephritis will develop in only 50%. The clinical presentation of lupus nephritis is highly variable, ranging from asymptomatic hematuria and/or proteinuria, to frank nephrotic syndrome, to rapidly progressive glomerulonephritis with loss of renal function. Lupus nephritis typically develops within the first 36 months of the disease, although there are exceptions