Determination of some benzodiazepines using N-bromosuccinimide: part I-litrimetric methods
Egyptian Journal of Pharmaceutical Sciences. 1991; 32 (3-4): 477-487
in English
| IMEMR
| ID: emr-19746
ABSTRACT
Diazepam, lormetazepam, chlorodemethyldiazepam and lorazepam representing 1,4-benzodiazepines are quantified using N- bromosuccinimide after being hydrolyzed in aqueous hydrochloric or sulfuric acids. The stoichiometry of the reaction is ascertained in each medium. Clobazam, a 1,5-benzodiazepine, is estimated by reaction of the intact drug in 1 9 DMF/4 M HCl with N-bromosuccinimide. The methods presented are successfully applied for the determination of the aforementioned drugs in their pharmaceutical formulations
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Bromosuccinimide
Language:
English
Journal:
Egypt. J. Pharm. Sci.
Year:
1991
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