Effect of silver nanoparticles on carbapenem resistant gram-negative bacteria

ABSTRACT

Background: Gram-negative bacteria are common causes of both community-acquired and hospital-acquired infections. beta-Lactam drugs are often the primary therapeutic option for serious infections, and carbapenems in particular are often considered agents of last resort. Thus, the emergence and spread of carbapenem-resistant [CR] bacteria are a significant public health concern. Infections with these resistant bacteria are associated with higher mortality rates than those for infections caused by carbapenem susceptible organisms. There have been considerable efforts to develop new antimicrobials drug against this type of resistant bacteria. Silver Nanoparticles [AgNPs] have emerged as promising weapons in the anti-microbial arsenal. Their anti-microbial efficacy is attributable to multiple mechanism of action